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KMID : 0359320200600010019
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Korean Journal of Veterinary Research
2020 Volume.60 No. 1 p.19 ~ p.24
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Clinical trial of oral administration of Bifidobacterium longum in dogs with atopic dermatitis
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Lee Kang-Il
Yun Tae-Sik
Ham Jun-Sang
Lee Wan-Kyu
Kang Ji-Houn
Yang Mhan-Pyo
Kang Byeong-Teck
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Abstract
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This study assessed the effects of probiotics in canine atopic dermatitis (AD). We enrolled 11 client-owned dogs with ADand randomly allocated them to two groups. The probiotics group (n = 7) was prescribed with Bifidobacterium longum while thecontrol group (n = 4) received a placebo powder once a day for 12 weeks. In both groups, the degree of skin lesions was evaluatedbased on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4. We also measured the transepidermal water loss(TEWL). We assessed pruritus severity using the pruritus visual analog scale (PVAS). Alteration of consumed drug doses wasconverted into medication scores. All the evaluation indices were surveyed every 4 weeks. In the probiotics group, there was asignificant decrease in the CADESI-4 score at 4, 8, and 12 weeks compared to that of the baseline score (p < 0.05). There was nosignificant difference in TEWL, PVAS, and medication score at each time point and between groups. Although these results showedthat Bifidobacterium longum did not reduce pruritus, TEWL, and the dosage of drugs for canine AD, it was effective in improving skinlesions, therefore, probiotics could be considered in canine AD with severe skin symptoms.
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KEYWORD
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Atopic dermatitis, Bifidobacterium longum, dogs, probiotics
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